Compression is a process of compressing, or increase in density or lessening in the bulk volume of granules or powder. Compaction is the process of alteration of powders into a coherent specimen or compacting powder or granules.
Table of Contents
What is physics of tablet compression?
Tablet compression physics includes: Transmission of forces during compression. Distribution of forces in tablets. The effect of applied pressure on the. relative volume of the powder. Interparticulate adhesion and cohesion.
What is compaction physics?
Compaction: compaction of a powder is a general term used to describe a situation in which powdered material is subjected to some level of mechanical force. The physics of compaction may be simply stated as the compression & consolidation of two phase (particulate solid & gas) systems due to the applied force.
Which forces are involved in compression of tablets?
Because most of particle have water, and moisture content is also pivotal to the tabletability. In die compaction, particles undergo compression and compactibility. At the compression stage, surface and friction contributions, such as those from van der Waals and electrostatic interactions, are more prevalent.
What is the principle of compression machine?
The basic principle behind the tablet compression machine is hydraulic pressure. This pressure is transmitted unreduced through the static fluid. Any externally applied pressure is transmitted via static fluid to all the directions in the same proportion.
How many types of compression machines are there?
TYPES OF COMPRESSION MACHINES There are following 2 types, i. SINGLE PUNCH/SINGLE STATION/ECCENTRIC PRESSES ii. MULTI-STATION/ROTARY PRESSES ๏ SINGLE PUNCH/SINGLE STATION/ECCENTRIC PRESSES ๏ผ Single punch tablet press also known as eccentric press or single station press is the simplest machine for tablet manufacturing.
What is compaction in tablet?
Compaction process of pharmaceutical powders consists of filling process of powders into a die, compressing process of filled powders in a die by upper and lower punches and ejection process of a compacted tablet from a die.
What is compaction in pharmaceutical industry?
Compaction is one method of producing granulates that uses pressure to minimize the space between individual particles. Both processes are essential to the production of pharmaceutical products such as pills, capsules, and tablets.
What is the difference between data compaction and data compression?
Data compression compresses the data blocks to reduce the amount of physical storage that is required. Data compaction stores more data in less space to increase storage efficiency.
What is compression and consolidation?
1. Compaction is the compression of soil by the expulsion of air from the voids of the soil. Consolidation is the compression of soil by the expulsion of water from voids of the soil.
What is powder compression?
Powder compression refers to the reduction in volume of a powder through the application of a force. This force via compression activity, then increases the proximity of particle surfaces, resulting to the formation of bonds between particles, thus, providing powder coherence: a compact is formed.
What is Kawakita equation?
The behavior of both the powder and its formulations in the tapping procedure were compared using numerical constants obtained from Kawakita plots. The Kawakita equation, which is used for assessing the flow properties of powders, is given by: N C = N a + 1 ab (2)
Why pre compression is done in tablet manufacturing?
Cause: Pre-compression is used to remove the entrapped air in the tablet which we discussed earlier. However, too much pre-compression will lead to manufacturing of thin tablets. Too thin thickness can lead to fractures or creation of another layer of the tablet.
What is tablet punching?
To make a tablet from powder, the granulated material is metered into a cavity formed by two punches (lower punch and upper punch) and a die. Then the punches are pressed together with a force to compress the material together in the middle die from opposite directions.
How do you use tablet press?
What is tooling in tablet compression?
Tooling can be defined as tools to craft a particular shape. Tabletting tools i.e., Punches and dies are essential tools to shape any granules into a solid dosage form by applying compaction force in a compression machine.
What is dwell time in tablet compression?
In tablet compression, dwell time is the time that the punch head remains in contact with the compression roller. It is defined as the amount of time that the compression force applied when forming the tablet is above 90% of its peak value.
What is D tooling and B tooling?
DB Tooling Punch Length and Diameter of DB tooling is similar that of D tooling but the die diameter varies between them. D tooling dies and punches are usually have a greater diameter of the tip of punches as compared to B type tolling which makes D type tooling ideal for compression of big size tablets.
Which oil is used in compression machine?
The oil type used in most Forney compression machines is Dexron III Automatic Transmission Fluid (ATF).
Which part of tablet compression machine is stationary?
Tablet Press Ejection Cam Remember, after compression, the tablet is always fixed within the die systems (space between lower and upper punches).
What is direct compression?
Direct compression (DC) is the most straightforward manufacturing option, with the fewest manufacturing steps, making it the easiest to control and least expensive. The direct compression tablet process uses two primary process steps: blending the API with excipients and compressing the finished tablets.
What is the difference between compressibility and consolidation?
Abstract. Compressibility and consolidation can be distinguished as: compressibility โ volume changes in a soil when subjected to pressure amounts of settlement. consolidation โ rate of volume change with time time to produce a given settlement.
Why is roller compaction used?
Roller compaction is a dry granulation process used in the pharmaceutical industry to create drug granules with suitable densification, drug content uniformity and powder flowability for manufacturing solid dosage forms such as tablets and capsules.
What is the difference between compressibility and compactibility?
The compressibility is the ability of a material to reduce its volume when a pressure is applied. As you can see here, the reduction of volume is expressed as an increase in solid fraction. The compactibility is the ability of a powder to give tablets of a specified strength when a reduction of volume occurs.
What is ejection force in tablet compression?
Ejection force is the force required the push the tablet out of the die. Ejection stress is calculated from ejection force to account for the punch and die geometries (Stress = Force/Area). It is a measure of how well lubricated the formulation is.